Parkin antibody (AA 62-80)

Catalog No. ABIN636324

The Rabbit Polyclonal anti-Parkin antibody (ABIN636324) specifically detects Parkin in WB and IP. The antibody is reactive with Human samples.

Quick Overview for Parkin antibody (AA 62-80) (ABIN636324)

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Parkin antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Parkin Antibody

Binding Specificity: AA 62-80

Purification: Affinity purified

Immunogen: PARK2 antibody was raised in rabbit using AA 62-80 DQQSIVHIVQRPWRKGQEM of the human 52 kDa Parkin protein as the immunogen.

Isotype: IgG

Application Details

Application Notes: IP: 1:250-1:1,000, WB: 1:250-1:1,000
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: Affinity purified IgG supplied in PBS with 0.02 % NaN3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.

Target Details for Parkin

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Alternative Name: PARK2

Background: Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin.

Pathways: Autophagy, Ubiquitin Proteasome Pathway