FST
Reactivity: Human
ELISA, IHC (f)
Host: Mouse
Monoclonal
unconjugated
Application Notes
ELISA: 0.5-2 µg/mL, Inhibition: 8-12 µg/mL, WB: 0.1-0.2 µg/mL Optimal conditions should be determined by the investigator.
Restrictions
For Research Use only
Format
Lyophilized
Concentration
Lot specific
Buffer
Lyophilized from PBS, pH 7.2.
Handling Advice
Avoid repeated freeze/thaw cycles. Dilute only prior to immediate use.
Storage
4 °C/-20 °C
Storage Comment
Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.
Follistatin is a secreted protein that binds to ligands of the TGF beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF beta ligands including BMP-2, -4, -6, -7, Myostatin, GDF-11, and TGF beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues.