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RANKL antibody

TNFSF11 Reactivity: Mouse WB, ELISA, Inhibition Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN636714
  • Target See all RANKL (TNFSF11) Antibodies
    RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
    Reactivity
    • 168
    • 130
    • 113
    • 46
    • 2
    • 2
    Mouse
    Host
    • 157
    • 31
    • 16
    • 5
    • 1
    Rabbit
    Clonality
    • 172
    • 36
    • 2
    Polyclonal
    Conjugate
    • 78
    • 18
    • 17
    • 11
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    This RANKL antibody is un-conjugated
    Application
    • 171
    • 78
    • 78
    • 64
    • 38
    • 30
    • 30
    • 20
    • 13
    • 12
    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Blocking Antibody (Inhibition)
    Purification
    Purified
    Immunogen
    RANKL antibody was raised in rabbit using highly pure recombinant murine sRANKL as the immunogen.
    Top Product
    Discover our top product TNFSF11 Primary Antibody
  • Application Notes
    ELISA: 0.5-2 µg/mL, Inhibition: 0.05 µg/mL, WB: 0.1-0.2 µg/mL
    Optimal conditions should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    Lot specific
    Buffer
    Lyophilized from PBS, pH 7.2.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.
  • Target
    RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
    Alternative Name
    RANKL (TNFSF11 Products)
    Synonyms
    CD254 antibody, ODF antibody, OPGL antibody, OPTB2 antibody, RANKL antibody, TRANCE antibody, hRANKL2 antibody, sOdf antibody, TNFSF11 antibody, Ly109l antibody, OPG antibody, Trance antibody, cd254 antibody, odf antibody, opgl antibody, optb2 antibody, rankl antibody, sodf antibody, tnfsf11 antibody, trance antibody, TNF superfamily member 11 antibody, tumor necrosis factor (ligand) superfamily, member 11 antibody, TNF receptor superfamily member 11b antibody, TNF superfamily member 11 L homeolog antibody, TNFSF11 antibody, Tnfsf11 antibody, TNFRSF11B antibody, tnfsf11.L antibody
    Background
    RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG.
    Molecular Weight
    19.4 kDa (predicted detection band MW)
    Pathways
    NF-kappaB Signaling
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