Prostaglandin E Synthase antibody

Catalog No. ABIN636994

Product Details anti-Prostaglandin E Synthase Antibody

Target: Prostaglandin E Synthase (PTGES)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Prostaglandin E Synthase antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Affinity chromatography purified

Immunogen: PTGES antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.

Application Details

Application Notes: IHC-P: 10 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1 % NaN3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Aliquot and store at -70 °C for long term storage.

Target Details for Prostaglandin E Synthase

Target: Prostaglandin E Synthase (PTGES)

Alternative Name: PTGES (PTGES Products)

Synonyms: ptges antibody, MGC80290 antibody, PTGES antibody, MGST-IV antibody, MGST1-L1 antibody, MGST1L1 antibody, MPGES antibody, PGES antibody, PIG12 antibody, PP102 antibody, PP1294 antibody, TP53I12 antibody, mPGES-1 antibody, 2410099E23Rik antibody, D2Ertd369e antibody, Pges antibody, mPGES antibody, MPGES-1 antibody, prostaglandin E synthase antibody, prostaglandin E synthase S homeolog antibody, PTGES antibody, ptges.S antibody, Ptges antibody

Background: Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene. The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.