HLA-ABC antibody

Catalog No. ABIN642915

This anti-HLA-ABC antibody is a Rat antibody detecting HLA-ABC in FACS, IP and IHC (fro). Suitable for Human.

Quick Overview for HLA-ABC antibody (ABIN642915)

Target: HLA-ABC

Reactivity: Human

Host: Rat

Conjugate: This HLA-ABC antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-HLA-ABC Antibody

Specificity: The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region. There are 3 major MHC class I proteins encoded by the HLA which are HLA A, HLA B and HLA C. These proteins are found on the surface of almost all nucleated somatic cells. DS-MB-01537 recognizes a monomorphic determinant on the human HLA Class I heavy chain. Epitope analysis has shown that this antibody binds in the alpha1 domain. Recent studies have shown that this antibody may be able to induce apoptosis in activated but not resting T cells (1).

Characteristics: Rat Anti-Human HLA ABC

Purification: Purified

Immunogen: PhA activated human peripheral blood lymphocytes.

Isotype: IgG2b

Application Details

Restrictions: For Research Use only

Handling

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for HLA-ABC

Target: HLA-ABC

Alternative Name: HLA ABC

Background: This antibody does not cross reacts with Fab or F(ab')2 of IgG. Some cross reaction with IgG of other species such as horse and sheep was observed. No cross reaction with human IgA, IgE or IgM.

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints