LDLRAP1 antibody

Catalog No. ABIN645905

The Goat not_set anti-LDLRAP1 antibody is suitable to detect LDLRAP1 in samples from Human and Mouse.

Quick Overview for LDLRAP1 antibody (ABIN645905)

Target: LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))

Reactivity: Human, Mouse

Host: Goat

Conjugate: This LDLRAP1 antibody is un-conjugated

Application: Please inquire

Product Details anti-LDLRAP1 Antibody

Specificity: The goat Anti-ARH / LDL receptor antibody detects protein derived from human recombinant protein and human liver lysate at various concentrations.

Cross-Reactivity: Human, Mouse (Murine)

Characteristics: Goat Anti-ARH / LDL Receptor adaptor

Immunogen: Peptide with sequence C-DALKSAGRALIRS, from the N Terminus of the protein sequence according to NP_056442.1, was used as immunogen.

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Reconstitution: Supplied as 100µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Storage: -20 °C

Target Details for LDLRAP1

Target: LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))

Background: LDLRAP1 is an adaptor protein that interacts with the cytoplasmic tail of low density lipoprotein receptor , phospholipids, and components of the clathrin endocytic machinery. LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDLR, LRP, Megalin, VLDLR and apoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. The LDL receptor is a cell surface transmembrane protein that mediates the uptake of low density lipoprotein and its degradation in the lysosome, which provides cholesterol to cells. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. Mutations in LDLR cause the autosomal dominant disease familial hypercholesterolemia (FH), which promotes premature coronary atherosclerosis.

NCBI Accession: NP_056442

Pathways: Lipid Metabolism