ADAM17 antibody (Domain 17)

Catalog No. ABIN647517

The Goat not_set anti-ADAM17 antibody (ABIN647517) specifically detects ADAM17. The antibody is reactive with Rat and Mouse samples.

Quick Overview for ADAM17 antibody (Domain 17) (ABIN647517)

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Reactivity: Rat, Mouse

Host: Goat

Conjugate: This ADAM17 antibody is un-conjugated

Application: Please inquire

Product Details anti-ADAM17 Antibody

Binding Specificity: Domain 17

Specificity: The ADAM17 goat antibody detects protein derived from human recombinant protein and HELA lysate at various concentrations.

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Characteristics: Goat Anti-ADAM17 / TACE, with HRP-conjugated secondary antibody

Immunogen: Peptide with sequence LQRQNRVDSKETEC, from the C Terminus of the protein sequence according to NP_003174.3. was used as immunogen.

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Reconstitution: Supplied as 100 µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Storage: -20 °C

Target Details for ADAM17

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Alternative Name: ADAM17 / TACE

Background: ADAM17, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme), CSVP, TACE, cSVP, CD156b, CD156b, MGC71942, TACE, cSVPADAM metallopeptidase domain 17, TNF-alpha converting enzyme, a disintegrin and metalloproteinase domain 17, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme), snake venom-like protease. Tumor necrosis factor beta (TNFbeta), also known as lymphotoxin, is a pleiotropic cytokine that has a molecular weight of 25 kDa. TNFalpha, also known as cachetin, is a 17 kDa cytokine that binds to the same receptors, producing an array of effects similar to those of TNFbeta. TNFbeta and TNFalpha share 30% amino acid homology and have similar biological activities. TNFbeta is produced by activated lymphocytes, including CD4+ T helper cell type 1 lymphocytes, CD8+ lymphocytes and certain B lymphoblastoid cell lines. TNFalpha is produced by several different cell types, including lymphocytes, neutrophils and macrophages. TNFbeta and TNFalpha can modulate many immune and inflammatory functions while having the ability to inhibit tumor growth. TACE (for TNFalpha converting enzyme) is a metalloproteinase that cleaves the membrane-bound TNFalpha precursor to release soluble TNFalpha.

NCBI Accession: NP_003174

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus