GNB1 antibody (N-Term)

Catalog No. ABIN651226

This Rabbit Polyclonal antibody specifically detects GNB1 in WB and FACS. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for GNB1 antibody (N-Term) (ABIN651226)

Target: GNB1 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 1 (GNB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNB1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB26119

Product Details anti-GNB1 Antibody

Binding Specificity: AA 1-30, N-Term

Predicted Reactivity: B, Ha, Zf, M, Rat, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GNB1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-GNB1 antibody (ABIN651226)

Liu, Qin, Yu, Soares, Yang, Weng, Li, Gao, Lu, Hu, Liu, Jiang, Liu, Shu, Tang, Liu: "Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish." in: The Journal of biological chemistry, Vol. 292, Issue 15, pp. 6225-6239, (2017) (PubMed).

Liu, Chen, Yu, Raghupathy, Liu, Qin, Li, Huang, Liao, Wang, Zou, Shu, Tang, Liu: "Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish." in: Human molecular genetics, Vol. 24, Issue 16, pp. 4648-59, (2015) (PubMed).

Target Details for GNB1

Target: GNB1 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 1 (GNB1))

Alternative Name: GNB1

Background: GNB1 integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This protein uses alternative polyadenylation signals.

Molecular Weight: 37377

Gene ID: 2782

NCBI Accession: NP_002065

UniProt: P62873

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Phototransduction, Thromboxane A2 Receptor Signaling, SARS-CoV-2 Protein Interactome