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XBP1 antibody (AA 62-91)

XBP1 Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB21824 unconjugated
Catalog No. ABIN651279
  • Target See all XBP1 Antibodies
    XBP1 (X-Box Binding Protein 1 (XBP1))
    Binding Specificity
    • 17
    • 16
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 62-91
    Reactivity
    • 68
    • 42
    • 10
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    Human
    Host
    • 67
    • 11
    • 1
    Rabbit
    Clonality
    • 67
    • 12
    Polyclonal
    Conjugate
    • 42
    • 7
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This XBP1 antibody is un-conjugated
    Application
    • 73
    • 44
    • 27
    • 19
    • 14
    • 13
    • 12
    • 8
    • 6
    • 4
    • 3
    • 3
    • 3
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    B, M, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This XBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-91 amino acids from the Central region of human XBP1.
    Clone
    RB21824
    Isotype
    Ig Fraction
    Top Product
    Discover our top product XBP1 Primary Antibody
  • Application Notes
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    XBP1 (X-Box Binding Protein 1 (XBP1))
    Alternative Name
    XBP1 (XBP1 Products)
    Synonyms
    treb5 antibody, xXBP1 antibody, xbp2 antibody, XBP1P1 antibody, XBPP1 antibody, xbp1 antibody, TREB5 antibody, XBP-1 antibody, XBP2 antibody, D11Ertd39e antibody, TREB-5 antibody, HTF antibody, cb918 antibody, id:ibd1195 antibody, trebf antibody, wu:fb02h05 antibody, wu:fb63f10 antibody, xbp1a antibody, xbp1b antibody, X-box binding protein 1 antibody, X-box binding protein 1 L homeolog antibody, xbp1 antibody, XBP1 antibody, Xbp1 antibody, xbp1.L antibody
    Background
    XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor.
    Molecular Weight
    28695
    Gene ID
    7494
    NCBI Accession
    NP_001073007, NP_005071
    UniProt
    P17861
    Pathways
    ER-Nucleus Signaling, Unfolded Protein Response
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