ARHGEF3 antibody (AA 211-240)

Catalog No. ABIN652003

This Rabbit Polyclonal antibody specifically detects ARHGEF3 in WB and IHC (p). It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for ARHGEF3 antibody (AA 211-240) (ABIN652003)

Target: ARHGEF3 (rho Guanine Nucleotide Exchange Factor (GEF) 3 (ARHGEF3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB27451

Product Details anti-ARHGEF3 Antibody

Binding Specificity: AA 211-240

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ARHGEF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-240 amino acids from the Central region of human ARHGEF3.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-ARHGEF3 antibody (ABIN652003)

Liu, Zheng, Cai, Guo, Lin, Chen, Liao, Kung, Zeng, Xie: "The putative tumor activator ARHGEF3 promotes nasopharyngeal carcinoma cell pathogenesis by inhibiting cellular apoptosis." in: Oncotarget, Vol. 7, Issue 18, pp. 25836-48, (2017) (PubMed).

Target Details for ARHGEF3

Target: ARHGEF3 (rho Guanine Nucleotide Exchange Factor (GEF) 3 (ARHGEF3))

Alternative Name: ARHGEF3

Background: Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 59783

Gene ID: 50650

NCBI Accession: NP_001122087, NP_001122088, NP_062455

UniProt: Q9NR81

Pathways: Neurotrophin Signaling Pathway