UNC13B antibody (AA 1062-1091)

Catalog No. ABIN2842552

This Rabbit Polyclonal antibody specifically detects UNC13B in WB and FACS. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for UNC13B antibody (AA 1062-1091) (ABIN2842552)

Target: UNC13B (Unc-13 Homolog B (UNC13B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC13B antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB22476

Product Details anti-UNC13B Antibody

Binding Specificity: AA 1062-1091

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1062-1091 amino acids from the Central region of human UNC13B.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-UNC13B antibody (ABIN2842552)

Kasmapour, Gronow, Bleck, Hong, Gutierrez: "Size-dependent mechanism of cargo sorting during lysosome-phagosome fusion is controlled by Rab34." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 50, pp. 20485-90, (2012) (PubMed).

Target Details for UNC13B

Target: UNC13B (Unc-13 Homolog B (UNC13B))

Alternative Name: UNC13B

Background: UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).

Molecular Weight: 180679

Gene ID: 10497

NCBI Accession: NP_006368

UniProt: O14795

Pathways: Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis