ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18) (AA 1066-1095), (C-Term) antibody

Details for Product No. ABIN652853, Supplier: Log in to see
Antigen
  • 9630038L21
  • ADAMTS21
  • E130314N14Rik
  • KNO2
  • RGD1560118
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
  • ADAM metallopeptidase with thrombospondin type 1 motif 18
  • ADAM metallopeptidase with thrombospondin type 1 motif, 18
  • Adamts18
  • ADAMTS18
Epitope
AA 1066-1095, C-Term
13
9
4
3
2
1
1
1
Reactivity
Human, Mouse (Murine)
44
27
6
2
2
2
2
1
1
1
1
Host
Rabbit
41
3
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
41
30
8
5
2
1
1
Options
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Immunogen This ADAMTS18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1066-1095 AA from the C-terminal region of human ADAMTS18.
Clone RB22477
Isotype Ig Fraction
Specificity This ADAMTS18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1073~1103 amino acids from the C-terminal region of human ADAMTS18.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Antigen
Alternative Name ADAMTS18 (ADAMTS18 Antibody Abstract)
Background ADAMTS18 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This protein has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor.
Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 18, ADAMTS-18, ADAM-TS 18, ADAM-TS18, ADAMTS18, ADAMTS21
Molecular Weight 135141 DA
Gene ID 170692
UniProt Q8TE60
Application Notes WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18) (AA 1066-1095), (C-Term) antibody (ABIN652853) Western blot analysis of ADAMTS18 Antibody (C-term) (ABIN652853) in mouse liver tissu...
Immunohistochemistry (IHC) image for anti-ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18) (AA 1066-1095), (C-Term) antibody (ABIN652853) Formalin-fixed and paraffin-embedded human brain tissue reacted with ADAMTS18 Antibod...
Western Blotting (WB) image for anti-ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18) (AA 1066-1095), (C-Term) antibody (ABIN652853) ADAMTS18 Antibody (C-term) (ABIN652853) western blot analysis in MDA-MB231 cell line ...
Product cited in: Reddy, Fernandes, Deshpande, Weisberg, Inguilizian, Abdel-Wahab, Kung, Levine, Griffin, Sattler: "The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity." in: Leukemia, Vol. 26, Issue 3, pp. 481-9, 2012 (PubMed).

Aldahmesh, Khan, Mohamed, Alkuraya, Ahmed, Bobis, Al-Mesfer, Alkuraya: "Identification of ADAMTS18 as a gene mutated in Knobloch syndrome." in: Journal of medical genetics, Vol. 48, Issue 9, pp. 597-601, 2011 (PubMed).

Background publications Jin, Wang, Ying, Wong, Li, Lee, Srivastava, Chan, Yeo, Ma, Putti, Lung, Shen, Xu, Langford, Tao: "Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas." in: Oncogene, Vol. 26, Issue 53, pp. 7490-8, 2007 (PubMed).

Zeng, Corcoran, Collins-Racie, Lavallie, Morris, Flannery: "Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18." in: Biochimica et biophysica acta, Vol. 1760, Issue 3, pp. 517-24, 2006 (PubMed).

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