HMGA1 antibody (C-Term)

Catalog No. ABIN653050

This Rabbit Polyclonal antibody specifically detects HMGA1 in WB, IF and FACS. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for HMGA1 antibody (C-Term) (ABIN653050)

Target: HMGA1 (High Mobility Group AT-Hook 1 (HMGA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMGA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: RB17645

Product Details anti-HMGA1 Antibody

Binding Specificity: AA 64-93, C-Term

Predicted Reactivity: Ha, M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This HMGA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-93 amino acids from the C-terminal region of human HMGA1.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000. WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-HMGA1 antibody (ABIN653050)

Liu, Zhang, Li, Ding, Tu, Zhou, Qi, Chen, Sun: "Let-7a inhibits growth and migration of breast cancer cells by targeting HMGA1." in: International journal of oncology, Vol. 46, Issue 6, pp. 2526-34, (2015) (PubMed).

Target Details for HMGA1

Target: HMGA1 (High Mobility Group AT-Hook 1 (HMGA1))

Alternative Name: HMGA1

Background: HMGA1 encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus.

Molecular Weight: 11676

Gene ID: 3159

NCBI Accession: NP_002122, NP_665906, NP_665908, NP_665909, NP_665910, NP_665912

UniProt: P17096

Pathways: Nuclear Hormone Receptor Binding, Autophagy