HDAC2 antibody (AA 410-439)

Catalog No. ABIN653718

This anti-HDAC2 antibody is a Rabbit Polyclonal antibody detecting HDAC2 in WB, IF, IHC (p) and FACS. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for HDAC2 antibody (AA 410-439) (ABIN653718)

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: RB24526

Product Details anti-HDAC2 Antibody

Binding Specificity: AA 410-439

Predicted Reactivity: C, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HDAC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-439 amino acids from the Central region of human HDAC2.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-HDAC2 antibody (ABIN653718)

Leucker, Nomura, Kim, Bhatta, Wang, Wecker, Jandu, Santhanam, Berkowitz, Romer, Pandey: "Cystathionine γ-lyase protects vascular endothelium: a role for inhibition of histone deacetylase 6." in: American journal of physiology. Heart and circulatory physiology, Vol. 312, Issue 4, pp. H711-H720, (2017) (PubMed).

Target Details for HDAC2

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Alternative Name: HDAC2

Background: This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Molecular Weight: 55364

Gene ID: 3066

NCBI Accession: NP_001518

UniProt: Q92769

Pathways: Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection