AMH antibody (AA 424-451)

Catalog No. ABIN653897

The Rabbit Polyclonal anti-AMH antibody has been validated for WB, FACS and IHC (p). It is suitable to detect AMH in samples from Human and Mouse. There are 2+ publications available.

Quick Overview for AMH antibody (AA 424-451) (ABIN653897)

Target: AMH (Anti-Mullerian Hormone (AMH))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AMH antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-AMH Antibody

Binding Specificity: AA 424-451

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This AMH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 424-451 amino acids of human AMH.

Isotype: IgG

Application Details

Application Notes: WB: 1:1000-1:2000. IHC-P: 1:25. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-AMH antibody (ABIN653897)

Jin, Won, Park, Lee, Park, Bae: "FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Müllerian Hormone in Human Granulosa Cells." in: PLoS ONE, Vol. 11, Issue 7, pp. e0159112, (2017) (PubMed).

Park, Suh, Lee, Bae: "Positive cross talk between FOXL2 and antimüllerian hormone regulates ovarian reserve." in: Fertility and sterility, (2014) (PubMed).

Target Details for AMH

Target: AMH (Anti-Mullerian Hormone (AMH))

Alternative Name: AMH

Background: Anti mullerian hormone (AMH) is a member of the TGF beta superfamily. It is secreted as a homodimeric 140kD disulphide linked precursor that is cleaved to release the mature 30kD homodimer. Originally classified as a foetal testicular hormone that inhibits Mullerian duct development, AMH is expressed post natally by immature Sertoli cells, and to a lesser degree by granulosa cells. AMH plays a role in testicular differentiation and in the regulation of ovarian follicle growth.

Molecular Weight: 59195

Gene ID: 268

NCBI Accession: NP_000470

UniProt: P03971

Pathways: Negative Regulation of Hormone Secretion