Neuroserpin antibody (N-Term)

Catalog No. ABIN654346

Product Details anti-Neuroserpin Antibody

Target: Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))

Binding Specificity: AA 19-45, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuroserpin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SERPINI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-45 amino acids from the N-terminal region of human SERPINI1.

Clone: RB28079

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for Neuroserpin

Target: Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))

Alternative Name: SERPINI1 (SERPINI1 Products)

Synonyms: PI12 antibody, neuroserpin antibody, AI837402 antibody, Ns antibody, PI-12 antibody, Spi17 antibody, CG9453 antibody, Dmel\\CG9453 antibody, Serp2 antibody, Sp4 antibody, Spn4 antibody, Spn4A antibody, dSerp2 antibody, sp4 antibody, spn4 antibody, raPIT5a antibody, SERPINI1 antibody, pi12 antibody, serpini1l antibody, si:ch211-167c22.4 antibody, serpin family I member 1 antibody, serine (or cysteine) peptidase inhibitor, clade I, member 1 antibody, Serpin 42Da antibody, serpin peptidase inhibitor, clade I (neuroserpin), member 1 antibody, serpin family I member 1 L homeolog antibody, SERPINI1 antibody, Serpini1 antibody, Spn42Da antibody, serpini1 antibody, serpini1.L antibody

Background: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Molecular Weight: 46427

Gene ID: 5274

NCBI Accession: NP_001116224, NP_005016

UniProt: Q99574

Pathways: Regulation of Hormone Metabolic Process