Complement C2 antibody (N-Term)

Catalog No. ABIN654619

This Rabbit Polyclonal antibody specifically detects Complement C2 in WB. It exhibits reactivity toward Human and Hamster.

Quick Overview for Complement C2 antibody (N-Term) (ABIN654619)

Target: Complement C2

Reactivity: Human, Hamster

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement C2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB18356

Product Details anti-Complement C2 Antibody

Binding Specificity: AA 147-176, N-Term

Specificity: This C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-180 amino acids from the N-terminal region of human C2.

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 AA from the N-terminal region of human C2.

Isotype: Ig Fraction

Application Details

Application Notes: WB = 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.26 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for Complement C2

Target: Complement C2

Alternative Name: C2

Background: Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
Synonyms: Complement C2,C2,

Molecular Weight: 83268 DA

Gene ID: 717

NCBI Accession: NP_000054

UniProt: P06681