Claudin 6 antibody (AA 130-159)

Catalog No. ABIN654669

Product Details anti-Claudin 6 Antibody

Target: Claudin 6 (CLDN6)

Binding Specificity: AA 130-159

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 6 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Zf

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CLDN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-159 amino acids from the Central region of human CLDN6.

Clone: RB24299

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for Claudin 6

Target: Claudin 6 (CLDN6)

Alternative Name: CLDN6 (CLDN6 Products)

Synonyms: cldn4l2 antibody, cldn6 antibody, CLDN6 antibody, AL024037 antibody, claudin 6, gene 1 L homeolog antibody, claudin 6 antibody, cldn6.1.L antibody, CLDN6 antibody, Cldn6 antibody

Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.

Molecular Weight: 23292

Gene ID: 9074

NCBI Accession: NP_067018

UniProt: P56747

Pathways: Hepatitis C