CYP2B6 antibody (AA 235-263)

Catalog No. ABIN655056

Cited in 2+ publications. The Rabbit Polyclonal anti-CYP2B6 antibody (Clone RB16992) (ABIN655056) specifically detects CYP2B6 in WB, IF and IHC (p). The antibody is reactive with Human samples.

Quick Overview for CYP2B6 antibody (AA 235-263) (ABIN655056)

Target: CYP2B6 (Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP2B6 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB16992

Product Details anti-CYP2B6 Antibody

Binding Specificity: AA 235-263

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CYP2B6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 amino acids from the Central region of human CYP2B6.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:25. WB: 1:2000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-CYP2B6 antibody (ABIN655056)

Okamatsu, Komatsu, Ono, Inoue, Uchide, Onaga, Endoh, Kitazawa, Hiraga, Uno, Teraoka: "Characterization of feline cytochrome P450 2B6." in: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 47, Issue 2, pp. 93-102, (2017) (PubMed).

Hlavá?, Brynychová, Václavíková, Ehrlichová, Vrána, Pecha, Trnková, Kodet, Mrhalová, Kubá?ková, Gat?k, Vážan, Sou?ek: "The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients." in: Medicine, Vol. 93, Issue 28, pp. e255, (2014) (PubMed).

Target Details for CYP2B6

Target: CYP2B6 (Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6))

Alternative Name: CYP2B6

Background: This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described, however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

Molecular Weight: 56278

Gene ID: 1555

NCBI Accession: NP_000758

UniProt: P20813