MLH1 antibody (AA 452-480)

Catalog No. ABIN655632

This anti-MLH1 antibody is a Rabbit Polyclonal antibody detecting MLH1 in WB and FACS. Suitable for Human.

Quick Overview for MLH1 antibody (AA 452-480) (ABIN655632)

Target: MLH1 (MutL Homolog 1 (MLH1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLH1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB18813

Product Details anti-MLH1 Antibody

Binding Specificity: AA 452-480

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 452-480 amino acids from the Central region of human MLH1.

Isotype: IgG

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for MLH1

Target: MLH1 (MutL Homolog 1 (MLH1))

Alternative Name: MLH1

Background: This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

Molecular Weight: 84601

Gene ID: 4292

NCBI Accession: NP_000240, NP_001161089, NP_001161090, NP_001161091, NP_001245200, NP_001245202, NP_001245203

UniProt: P40692

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response