TRIM5 antibody (C-Term)

Catalog No. ABIN655693

This Rabbit Polyclonal antibody specifically detects TRIM5 in WB. It exhibits reactivity toward Human.

Quick Overview for TRIM5 antibody (C-Term) (ABIN655693)

Target: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM5 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB29688

Product Details anti-TRIM5 Antibody

Binding Specificity: AA 371-399, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TRIM5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371-399 amino acids from the C-terminal region of human TRIM5.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for TRIM5

Target: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Alternative Name: TRIM5

Background: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Molecular Weight: 56338

Gene ID: 85363

NCBI Accession: NP_149023, NP_149083, NP_149084

UniProt: Q9C035

Pathways: Activation of Innate immune Response