CLCN7 antibody (C-Term)

Catalog No. ABIN655808

There is 1 publication for this product available. The Rabbit Polyclonal anti-CLCN7 antibody is suitable to detect CLCN7 in samples from Human. It has been validated for WB, IF and IHC (p).

Quick Overview for CLCN7 antibody (C-Term) (ABIN655808)

Target: CLCN7 (Chloride Channel, Voltage-Sensitive 7 (CLCN7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLCN7 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB31756

Product Details anti-CLCN7 Antibody

Binding Specificity: AA 692-720, C-Term

Predicted Reactivity: B, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CLCN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-720 amino acids from the C-terminal region of human CLCN7.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-CLCN7 antibody (ABIN655808)

Yoshimoto, Morita, Matsubara, Mitsuyasu, Imai, Kajioka, Yoneda, Ito, Hirofuji, Nakamura, Hirata: "Surface vacuolar ATPase in ameloblastoma contributes to tumor invasion of the jaw bone." in: International journal of oncology, Vol. 48, Issue 3, pp. 1258-70, (2016) (PubMed).

Target Details for CLCN7

Target: CLCN7 (Chloride Channel, Voltage-Sensitive 7 (CLCN7))

Alternative Name: CLCN7

Background: The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood.

Molecular Weight: 88679

Gene ID: 1186

NCBI Accession: NP_001107803, NP_001278

UniProt: P51798