This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This JMJD2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 428-459 amino acids from the N-terminal region of human JMJD2B.
KDM4B is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. It does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20' and only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.