TGIF1 antibody (AA 145-174)

Catalog No. ABIN656000

The Rabbit Polyclonal anti-TGIF1 antibody has been validated for WB. It is suitable to detect TGIF1 in samples from Human.

Quick Overview for TGIF1 antibody (AA 145-174) (ABIN656000)

Target: TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGIF1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB14111

Product Details anti-TGIF1 Antibody

Binding Specificity: AA 145-174

Predicted Reactivity: C

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 amino acids from the Central region of human TGIF1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for TGIF1

Target: TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))

Alternative Name: TGIF1

Background: The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.

Molecular Weight: 43013

Gene ID: 7050

NCBI Accession: NP_001265611, NP_001265613, NP_001265615, NP_003235, NP_733796, NP_775299, NP_775300, NP_775301, NP_775302, NP_775303, NP_777480

UniProt: Q15583

Pathways: Retinoic Acid Receptor Signaling Pathway, Chromatin Binding, Tube Formation