TGIF1 antibody (AA 123-272)

Catalog No. ABIN7270795

This Rabbit Polyclonal antibody specifically detects TGIF1 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for TGIF1 antibody (AA 123-272) (ABIN7270795)

Target: TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGIF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TGIF1 Antibody

Binding Specificity: AA 123-272

Purpose: TGIF1 Rabbit pAb

Sequence: VESVMGIKNF MPALEETPFH SCTAGPNPTL GRPLSPKPSS PGSVLARPSV ICHTTVTALK DVPFSLCQSV GVGQNTDIQQ IAAKNFTDTS LMYPEDTCKS GPSTNTQSGL FNTPPPTPPD LNQDFSGFQL LVDVALKRAA EMELQAKLTA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 123-272 of human TGIF1 (NP_003235.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TGIF1

Target: TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))

Alternative Name: TGIF1

Background: The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described.,TGIF1,HPE4,TGIF,Epigenetics & Nuclear Signaling,Transcription Factors,Nuclear Receptor Signaling,Signal Transduction,Cell Biology & Developmental Biology,Neuroscience,Stem Cells,Embryonic Stem Cells,Neural Stem Cells,Target gene,TGIF1

Gene ID: 7050

UniProt: Q15583

Pathways: Retinoic Acid Receptor Signaling Pathway, Chromatin Binding, Tube Formation