HYAL2 antibody (AA 128-157)

Catalog No. ABIN656422

This Rabbit Polyclonal antibody specifically detects HYAL2 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for HYAL2 antibody (AA 128-157) (ABIN656422)

Target: HYAL2 (Hyaluronidase-2 (HYAL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HYAL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB31073

Product Details anti-HYAL2 Antibody

Binding Specificity: AA 128-157

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HYAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human HYAL2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: HYAL2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for HYAL2

Target: HYAL2 (Hyaluronidase-2 (HYAL2))

Alternative Name: HYAL2

Background: This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.

Molecular Weight: 53860

Gene ID: 8692

NCBI Accession: NP_003764, NP_149348

UniProt: Q12891

Pathways: Transition Metal Ion Homeostasis, Glycosaminoglycan Metabolic Process