PC (AA 53-82), (N-Term) antibody

Catalog No. ABIN656425

Product Details

Target: PC

Binding Specificity: AA 53-82, N-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This PC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-82 amino acids from the N-terminal region of human PC.

Predicted Reactivity: Cow (Bovine),Rat (Rattus)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 AA from the N-terminal region of human PC.

Clone: RB31105

Isotype: Ig Fraction

Application Details

Application Notes: WB = 1:1000, IHC (p) = 1:10-50

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: PC Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details

Target: PC

Background: This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq].
Synonyms: Pyruvate carboxylase, mitochondrial,PC,

Molecular Weight: 129634 DA

Gene ID: 5091

NCBI Accession: NP_000911, NP_001035806, NP_071504

UniProt: P11498