Synonyms: Aryl hydrocarbon hydroxylase,CP 12,CP12,CP1A2,CYP1A2,CYPIA2,Cytochrome P(3)450,Cytochrome P450 1A2,Cytochrome P450 4,Cytochrome P450 family 1 polypeptide 2,Cytochrome P450 family 1 subfamily A polypeptide 2,Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2,Cytochrome P450-P3,Cytochrome P4501A2,Dioxin inducable P3 450,Flavoprotein linked monooxygenase,Microsomal monooxygenase,P(3)450,P3 450,P450 4,P450 form 4,P450 P3,P450(PA),Xenobiotic monooxygenase
Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown, however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.