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Synonyms: Akt2,AKT2,HIHGHH,murine thymoma viral (v-akt) homolog-2,PKB,PKB beta,PKBB,PKBBETA,PRKBB,Protein kinase Akt 2,Protein kinase Akt-2,Protein kinase B beta,rac protein kinase beta,RAC-BETA,RAC-beta serine/threonine-protein kinase,RAC-PK-beta,v akt murine thymoma viral oncogene homolog 2
Background: This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.