FGFR3 antibody

Catalog No. ABIN6566588

This Rabbit Polyclonal antibody specifically detects FGFR3 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for FGFR3 antibody (ABIN6566588)

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFR3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FGFR3 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human FGFR3

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FGFR3

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Alternative Name: FGFR3

Background:

Synonyms: ACH,CD 333,CD333,CD333 antigen,CEK 2,CEK2,FGFR 3,FGFR-3,FGFR3,FGFR3,Fibroblast growth factor receptor 3 (achondroplasia thanatophoric dwarfism),Fibroblast growth factor receptor 3,Heparin binding growth factor receptor,HSFGFR3EX,Hydroxyaryl protein kinase,JTK 4,JTK4,MFR 3,SAM 3,Tyrosine kinase JTK 4,Tyrosine kinase JTK4,Z FGFR 3

Background: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Molecular Weight:

Observed_MW: 115kDa

Calculated_MW: 75kDa/85kDa/87kDa/88kDa

Gene ID: 2261

UniProt: P22607

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding