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- Target See all GEN1 Antibodies
- GEN1 (Gen Endonuclease Homolog 1 (GEN1))
- Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GEN1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human GEN1
- Isotype
- IgG
- Top Product
- Discover our top product GEN1 Primary Antibody
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anti-Gen Endonuclease Homolog 1 (GEN1) (AA 60-89), (N-Term) antibody
GEN1 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal RB23975 unconjugated
anti-Gen Endonuclease Homolog 1 (GEN1) (AA 669-908) antibodyGEN1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500 - 1:2000
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- GEN1 (Gen Endonuclease Homolog 1 (GEN1))
- Alternative Name
- GEN1 (GEN1 Products)
- Background
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Synonyms: DKFZp781F0986,Flap endonuclease GEN homolog 1,FLJ40869,GEN 1,Gen,Gen homolog 1 endonuclease (Drosophila),Gen homolog 1 endonuclease,GEN,GEN1
Background: This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.
- Molecular Weight
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Observed_MW: 103kDa
Calculated_MW: 102kDa
- Gene ID
- 348654
- UniProt
- Q17RS7
- Pathways
- DNA Damage Repair
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