MRPS12 antibody

Catalog No. ABIN6566989

This Rabbit Polyclonal antibody specifically detects MRPS12 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MRPS12 antibody (ABIN6566989)

Target: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRPS12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MRPS12 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human MRPS12

Isotype: IgG

Application Details

Application Notes: WB 1:1000 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MRPS12

Target: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Alternative Name: MRPS12

Background:

Synonyms: 28S ribosomal protein S12,28S ribosomal protein S12 mitochondrial,mitochondrial,Mitochondrial ribosomal protein S12,MRP-S12,MRPS12,MT-RPS12,RPMS12,RPS12,RPSM12,RT12,S12mt

Background: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene, all three variants encode the same protein.

Molecular Weight:

Observed_MW: 14kDa

Calculated_MW: 15kDa

Gene ID: 6183

UniProt: O15235

Pathways: Sensory Perception of Sound