IRAK4 antibody (N-Term)

Catalog No. ABIN656802

This anti-IRAK4 antibody is a Rabbit Polyclonal antibody detecting IRAK4 in WB. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for IRAK4 antibody (N-Term) (ABIN656802)

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRAK4 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB33094

Product Details anti-IRAK4 Antibody

Binding Specificity: AA 25-52, N-Term

Predicted Reactivity: B, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IRAK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-52 amino acids from the N-terminal region of human IRAK4.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: IRAK4 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-IRAK4 antibody (ABIN656802)

Ren, Sun, Deng, Zhang, Wu, Wei, Mani, Dou, Wang: "The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 309, Issue 7, pp. G517-27, (2015) (PubMed).

Target Details for IRAK4

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Alternative Name: IRAK4

Background: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 51530

Gene ID: 51135

NCBI Accession: NP_001107654, NP_001138728, NP_001138729, NP_001138730, NP_057207

UniProt: Q9NWZ3

Pathways: NF-kappaB Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades