TBL1X antibody

Catalog No. ABIN6568571

This Rabbit Polyclonal antibody specifically detects TBL1X in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TBL1X antibody (ABIN6568571)

Target: TBL1X (Transducin (Beta)-Like 1X-Linked (TBL1X))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBL1X antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TBL1X Antibody

Purification: Affinity purification

Immunogen: A synthetic peptide of human TBL1X

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TBL1X

Target: TBL1X (Transducin (Beta)-Like 1X-Linked (TBL1X))

Alternative Name: TBL1X

Background:

Synonyms: EBI,F box like/WD repeat protein TBL1X,F-box-like/WD repeat-containing protein TBL1X,SMAP 55,SMAP55,TBL 1,TBL 1X,TBL1,TBL1X,TBL1X,Transducin (beta) like 1,Transducin (beta) like 1 X linked,Transducin (beta) like 1X linked,Transducin beta like 1 X linked,Transducin beta like 1X,Transducin beta like 1X protein,Transducin beta like protein 1,X linked,Transducin beta-like protein 1X,Transducin-beta-like protein 1,X-linked

Background: The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.

Molecular Weight:

Observed_MW: 60kDa

Calculated_MW: 57kDa/62kDa

Gene ID: 6907

UniProt: O60907

Pathways: Sensory Perception of Sound, Regulation of Lipid Metabolism by PPARalpha