GRIA4 antibody (AA 296-325)

Catalog No. ABIN656865

This anti-GRIA4 antibody is a Rabbit Polyclonal antibody detecting GRIA4 in WB and IHC (p). Suitable for Human and Mouse. This Primary Antibody has been cited in 1 publication.

Quick Overview for GRIA4 antibody (AA 296-325) (ABIN656865)

Target: GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIA4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB30232

Product Details anti-GRIA4 Antibody

Binding Specificity: AA 296-325

Predicted Reactivity: Pr, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GRIA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the Central region of human GRIA4.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: GRIA4 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-GRIA4 antibody (ABIN656865)

Muntané, Horvath, Hof, Ely, Hopkins, Raghanti, Lewandowski, Wray, Sherwood: "Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission." in: Cerebral cortex (New York, N.Y. : 1991), Vol. 25, Issue 6, pp. 1596-607, (2015) (PubMed).

Target Details for GRIA4

Target: GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))

Alternative Name: GRIA4

Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA, R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq].

Molecular Weight: 100871

Gene ID: 2893

NCBI Accession: NP_000820, NP_001070711, NP_001070712, NP_001106283

UniProt: P48058

Pathways: PI3K-Akt Signaling