SPAM1 antibody
-
- Target See all SPAM1 Antibodies
- SPAM1 (Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))
- Reactivity
- Human, Mouse, Rat
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This SPAM1 antibody is un-conjugated
-
Application
- Immunofluorescence (IF)
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein of human SPAM1 (NP_003108.2).
- Isotype
- IgG
- Top Product
- Discover our top product SPAM1 Primary Antibody
-
-
- Application Notes
- IF 1:50-1:200
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- SPAM1 (Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))
- Alternative Name
- SPAM1 (SPAM1 Products)
- Synonyms
- AV039194 antibody, Ph-20 antibody, PH-20 antibody, PH20 antibody, HYA1 antibody, HYAL1 antibody, HYAL3 antibody, HYAL5 antibody, SPAG15 antibody, Spam antibody, XEH1 antibody, spam1 antibody, im:6902904 antibody, zgc:158668 antibody, sperm adhesion molecule 1 antibody, sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog antibody, sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) antibody, Spam1 antibody, SPAM1 antibody, spam1.L antibody, spam1 antibody
- Background
- Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1, another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
- Molecular Weight
-
Observed_MW: 47kDa
Calculated_MW: 57kDa/58kDa
- Gene ID
- 6677
- UniProt
- P38567
-