PLAU antibody

Catalog No. ABIN6569163

The Rabbit Polyclonal anti-PLAU antibody (ABIN6569163) specifically detects PLAU in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PLAU antibody (ABIN6569163)

Target: PLAU (Plasminogen Activator, Urokinase (PLAU))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAU antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PLAU Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human PLAU

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PLAU

Target: PLAU (Plasminogen Activator, Urokinase (PLAU))

Alternative Name: PLAU

Background:

Synonyms: ATF,ATF uPA,BDPLT5,Plasminogen activator,Plasminogen activator urinary,Plasminogen activator urokinase,PLAU,QPD,u PA,U plasminogen activator,u-PA,U-plasminogen activator,uPA,URK,UROK,Urokinase plasminogen activator,Urokinase type plasminogen activator,Urokinase type plasminogen activator precursor,Urokinase-type plasminogen activator chain B

Background: This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Molecular Weight:

Observed_MW: 45kDa

Calculated_MW: 46kDa/48kDa

Gene ID: 5328

UniProt: P00749

Pathways: Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration