Dynamin 1-Like antibody

Catalog No. ABIN6569298

Product Details anti-Dynamin 1-Like Antibody

Target: Dynamin 1-Like (DNM1L)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dynamin 1-Like antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Affinity purification

Immunogen: Recombinant protein of human DNM1L

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Dynamin 1-Like

Target: Dynamin 1-Like (DNM1L)

Alternative Name: DRP1 (DNM1L Products)

Background:

Synonyms: DLP1,dnm1l,DNM1L,Dnm1p/Vps1p-like protein,dnml1,DRP1,DVLP,Dymple,Dynamin 1 like,Dynamin family member proline-rich carboxyl-terminal domain less,Dynamin like protein,Dynamin related protein 1,Dynamin-1-like protein,Dynamin-like protein 4,Dynamin-like protein,Dynamin-like protein IV,Dynamin-related protein 1,DYNIV 11,EMPF,EMPF1,FLJ41912,HdynIV,VPS1

Background: This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight:

Observed_MW: 78-82kDa

Calculated_MW: 60kDa/78kDa/79kDa/80kDa/81kDa/82kDa/83kDa

Gene ID: 10059

UniProt: O00429