HFE2 antibody

Catalog No. ABIN6569858

This Rabbit Polyclonal antibody specifically detects HFE2 in WB. It exhibits reactivity toward Human and Rat.

Quick Overview for HFE2 antibody (ABIN6569858)

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HFE2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HFE2 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human HFE2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HFE2

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Alternative Name: HFE2

Background:

Synonyms: 2310035L15Rik,5230400G09Rik ,AI414844,AI789733,DL M,Haemojuvelin,HEMOCHROMATOSIS,HEMOCHROMATOSIS DUE TO DEFECT IN HEMOJUVELIN,HEMOCHROMATOSIS DUE TO DEFECT IN HEPCIDIN ANTIMICROBIAL PEPTIDE,HEMOCHROMATOSIS JUVENILE,Hemochromatosis type 2 (juvenile),Hemochromatosis type 2,Hemochromatosis type 2 protein,Hemochromatosis type 2 protein homolog,HEMOCHROMATOSIS, TYPE 2A,HEMOCHROMATOSIS, TYPE 2B,Hemojuvelin,HFE 2,Hfe2,HFE2A,HJV,JH,Juvenile,MGC23953,OTTHUMP00000059680,Repulsive guidance molecule c,RGM C,RGM domain family member C,RGMC

Background: The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Molecular Weight:

Observed_MW: 48kDa

Calculated_MW: 21kDa/33kDa/45kDa

Gene ID: 148738

UniProt: Q6ZVN8

Pathways: Transition Metal Ion Homeostasis