PDE6A antibody (AA 308-336)

Catalog No. ABIN657144

The Rabbit Polyclonal anti-PDE6A antibody (Clone RB33012) (ABIN657144) specifically detects PDE6A in WB. The antibody is reactive with Human samples.

Quick Overview for PDE6A antibody (AA 308-336) (ABIN657144)

Target: PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE6A antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB33012

Product Details anti-PDE6A Antibody

Binding Specificity: AA 308-336

Predicted Reactivity: B, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDE6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDE6A.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for PDE6A

Target: PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))

Alternative Name: PDE6A

Background: This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

Molecular Weight: 99547

NCBI Accession: NP_000431

UniProt: P16499

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction