Cortactin antibody (AA 273-302)

Catalog No. ABIN657649

This Rabbit Polyclonal antibody specifically detects Cortactin in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Cortactin antibody (AA 273-302) (ABIN657649)

Target: Cortactin (CTTN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cortactin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB33698

Product Details anti-Cortactin Antibody

Binding Specificity: AA 273-302

Predicted Reactivity: C

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CTTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the Central region of human CTTN.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: CTTN Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for Cortactin

Target: Cortactin (CTTN)

Alternative Name: CTTN

Background: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.

Molecular Weight: 61586

Gene ID: 2017

NCBI Accession: NP_001171669, NP_005222, NP_612632

UniProt: Q14247

Pathways: MAPK Signaling