CR1L antibody (AA 300-350)

Catalog No. ABIN6579446

The Rabbit Polyclonal anti-CR1L antibody is suitable to detect CR1L in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for CR1L antibody (AA 300-350) (ABIN6579446)

Target: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CR1L antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CR1L Antibody

Binding Specificity: AA 300-350

Purpose: CD35 Antibody

Specificity: CD35 Polyclonal Antibody detects endogenous levels of CD35

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human CR1/CR1L. AA range:300-350 & 740-790

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000, ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for CR1L

Target: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Alternative Name: CR1/CR1L

Background:

Synonyms: complement component (3b/4b) receptor 1/2 (Knops blood group)

Background: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants

Protein Name: CD35

Molecular Weight: '220 kDa

Gene ID: 1378, 1379

UniProt: P17927

Pathways: Complement System