GSTA1 antibody

Catalog No. ABIN659176

This Mouse Monoclonal antibody specifically detects GSTA1 in WB. It exhibits reactivity toward Human.

Quick Overview for GSTA1 antibody (ABIN659176)

Target: GSTA1 (Glutathione S-Transferase alpha 1 (GSTA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GSTA1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 286CT8-1-5

Product Details anti-GSTA1 Antibody

Purification: This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Immunogen: This GSTA1 monoclonal antibody is generated from mouse immunized with GSTA1 recombinant protein.

Isotype: IgM kappa

Application Details

Application Notes: WB: 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: GSTA1 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for GSTA1

Target: GSTA1 (Glutathione S-Transferase alpha 1 (GSTA1))

Alternative Name: GSTA1

Background: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

Molecular Weight: 25631

Gene ID: 2938

NCBI Accession: NP_665683

UniProt: P08263