P-Cadherin antibody (AA 126-336)

Catalog No. ABIN6654133

The Rabbit Polyclonal anti-P-Cadherin antibody has been validated for WB, ELISA and IHC (p). It is suitable to detect P-Cadherin in samples from Human, Mouse and Rat.

Quick Overview for P-Cadherin antibody (AA 126-336) (ABIN6654133)

Target: P-Cadherin (CDH3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P-Cadherin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-P-Cadherin Antibody

Binding Specificity: AA 126-336

Purification: Antigen affinity purified

Immunogen: Amino acids Q126-H336 from the human protein were used as the immunogen for the CDH3 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CDH3 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,Direct ELISA: 0.1-0.5 μg/mL (recombinant human protein)

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the CDH3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for P-Cadherin

Target: P-Cadherin (CDH3)

Alternative Name: P-Cadherin / CDH3

Background: Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.

UniProt: P22223