Aurora Kinase B antibody (AA 89-251)

Catalog No. ABIN6654235

The Rabbit Monoclonal anti-Aurora Kinase B antibody has been validated for IHC (p). It is suitable to detect Aurora Kinase B in samples from Human.

Quick Overview for Aurora Kinase B antibody (AA 89-251) (ABIN6654235)

Target: Aurora Kinase B (AURKB)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Aurora Kinase B antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ARRK2-2R

Product Details anti-Aurora Kinase B Antibody

Binding Specificity: AA 89-251

Purification: Purified

Purity: Protein A affinity

Immunogen: A portion of amino acids 89-251 was used as the immunogen for this recombinant AURKB antibody.

Isotype: IgG kappa

Application Details

Application Notes: Optimal dilution of the recombinant AURKB antibody should be determined by the researcher.\. IHC (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant AURKB antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for Aurora Kinase B

Target: Aurora Kinase B (AURKB)

Alternative Name: Aurora B / AURKB

Background: Recognizes a protein of 39 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

Pathways: TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades