NGFR antibody (AA 281-421)

Catalog No. ABIN6654291

This Rabbit Monoclonal antibody specifically detects NGFR in IHC (p). It exhibits reactivity toward Human.

Quick Overview for NGFR antibody (AA 281-421) (ABIN6654291)

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This NGFR antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: NGFR-2550R

Product Details anti-NGFR Antibody

Binding Specificity: AA 281-421

Purification: Purified

Purity: Protein A affinity chromatography

Immunogen: A portion of amino acids 281-421 from the human protein was used as the immunogen for the recombinant NGFR antibody.

Isotype: IgG kappa

Application Details

Application Notes: Optimal dilution of the recombinant NGFR antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant NGFR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for NGFR

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Alternative Name: NGF Receptor / p75NTR / CD271

Background: This antibody is specific for a glycoprotein of 75 kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or p75 Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR/p75NTR is a reliable marker for desmoplastic and neurotropic melanomas. It is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR/p75NTR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding