Cathepsin K antibody (AA 163-274)

Catalog No. ABIN6654326

The Mouse Monoclonal anti-Cathepsin K antibody (Clone CTSK-2791) (ABIN6654326) specifically detects Cathepsin K in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Cathepsin K antibody (AA 163-274) (ABIN6654326)

Target: Cathepsin K (CTSK)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cathepsin K antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CTSK-2791

Product Details anti-Cathepsin K Antibody

Binding Specificity: AA 163-274

Purpose: Cathepsin K Antibody / CTSK

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 163-274 from the human protein was used as the immunogen for the Cathepsin K antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Cathepsin K antibody to be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Cathepsin K antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Cathepsin K

Target: Cathepsin K (CTSK)

Alternative Name: Cathepsin K

Background: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades