Neuregulin 1 antibody (AA 21-242)

Catalog No. ABIN6654436

The Mouse Monoclonal anti-Neuregulin 1 antibody has been validated for IHC (p). It is suitable to detect Neuregulin 1 in samples from Human.

Quick Overview for Neuregulin 1 antibody (AA 21-242) (ABIN6654436)

Target: Neuregulin 1 (NRG1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neuregulin 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: NRG1-2752

Product Details anti-Neuregulin 1 Antibody

Binding Specificity: AA 21-242

Purification: Purified

Purity: Protein G affinity chromatography

Immunogen: A portion of amino acids 21-242 from the human protein was used as the immunogen for this Neuregulin-1 antibody.

Isotype: IgG

Application Details

Application Notes: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the Neuregulin-1 antibody to be titered up or down for optimal performance.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunofluorescence: 1-2 μg/mL for 30 min at RT

Restrictions: For Research Use only

Handling

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Neuregulin-1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for Neuregulin 1

Target: Neuregulin 1 (NRG1)

Alternative Name: Neuregulin-1 / NRG1

Background: Heregulin-1 / Neuregulin-1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation