CD81 antibody

Catalog No. ABIN6654863

The Rabbit Monoclonal anti-CD81 antibody (Clone C81-2885R) (ABIN6654863) specifically detects CD81 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for CD81 antibody (ABIN6654863)

Target: CD81

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD81 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: C81-2885R

Product Details anti-CD81 Antibody

Purification: Purified

Purity: Protein A affinity chromatography

Immunogen: A Burkitt lymphoma derived B-cell line was used as the immunogen for the recombinant CD81 antibody.

Isotype: IgG kappa

Application Details

Application Notes: Optimal dilution of the recombinant CD81 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 2-4 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant CD81 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for CD81

Target: CD81

Alternative Name: CD81

Background: Recognizes a protein of 26 kDa, identified as CD81 (Workshop VI, Code CD81.1). CD81 has a very broad cellular distribution, being expressed on T- and B-lymphocytes, NK cells, thymocytes, eosinophils, fibroblasts, epithelial and endothelial cells. Neutrophils, erythrocytes and platelets are negative, while monocytes are variably positive. CD81 is a member of a family of tetraspans transmembrane proteins, including CD9, CD37, CD53, CD63, and CD82. It associates with CD19, CD21, Leu 13, and integrins on cell membrane and is involved in signal transduction in B lymphocyte development and cell adhesion. CD81 also acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas.

Pathways: Inositol Metabolic Process, Hepatitis C