IL3RA antibody (AA 26-171)

Catalog No. ABIN6654876

This Rabbit Monoclonal antibody specifically detects IL3RA in IHC (p). It exhibits reactivity toward Human.

Quick Overview for IL3RA antibody (AA 26-171) (ABIN6654876)

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This IL3RA antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IL3RA-2947R

Product Details anti-IL3RA Antibody

Binding Specificity: AA 26-171

Purification: Purified

Purity: Protein A affinity chromatography

Immunogen: A portion of amino acids 26-171 was used as the immunogen for the recombinant CD123 antibody.

Isotype: IgG kappa

Application Details

Application Notes: Optimal dilution of the recombinant CD123 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.25-0.5 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant CD123 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for IL3RA

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Alternative Name: IL3RA / CD123

Background: CD123 is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudo-autosomal region on chromosomes X or Y.

Pathways: JAK-STAT Signaling